Ulrike Luderer, MD, PhD, MPH

Director of UCI Center for Occupational & Environmental Health
SCERC Targeted Research Training Program Co-Director

Professor
Environmental & Occupational Health, Public Health
School of Biological Sciences
School of Medicine

Univeristy of California, Irvine
Center for Occupational and Environmental Health
100 Theory Drive, Suite 100
Irvine, CA 92617

Phone: 949-824-8641
Email: uluderer@uci.edu

Research Publications

Toxicant effects on mammalian oocyte mitochondria†

Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†. 

Reproductive hazards of space travel in women and men. 

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.

In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses That Deplete Ovarian Follicles in Mice. 

Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis. 

Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors. 

Very low doses of heavy oxygen ion radiation induce premature ovarian failure

Transitions in pregnancy planning in women recruited for a large prospective cohort study

Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. 

Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women.

Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary

The Mouse Fetal Ovary Has Greater Sensitivity Than the Fetal Testis to Benzo[a]pyrene-Induced Germ Cell Death

Charged iron particles, components of space radiation, destroy ovarian follicles

Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice

Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure

Concepts and challenges in cancer risk prediction for the space radiation environment. 

Reprint of “In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective”. 

Ovarian toxicity from reactive oxygen species.

 In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective. 

Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women.

Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. 

Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice. 

Roles of reactive oxygen species and antioxidants in ovarian toxicity. 

Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. 

Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary. 

Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. 

Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells. 

Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. 

Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. 

Induction of apoptosis by 9,10-dimethyl-1,2-benzanthracene in cultured preovulatory rat follicles is preceded by a rise in reactive oxygen species and is prevented by glutathione. 

Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. 

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene. 

Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. 

Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine.

Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific.

Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men

Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis

Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats

Temporal association between serum prolactin concentration and exposure to styrene

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane

Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis

Gonadotropin regulation of glutathione synthesis in the rat ovary

Reproductive endocrine effects of acute exposure to toluene in men and women

Calls on reproductive and developmental toxicants to a regional poison center

Acute changes in pulsatile LH and FSH secretion after ovariectomy in rats: treatment with oestradiol for 24 h suppresses LH, but not FSH, for at least 48 h

Differential gonadotropin responses to N-methyl-D,L-aspartate in metestrous, proestrous, and ovariectomized rats

Differential gonadotropin responses to N-methyl-D,L-aspartate in intact and castrated male rats

Sex differences in acute luteinizing hormone responses to gonadectomy remain after progesterone antagonist and dopamine agonist treatment